PRP Skin Regeneration Therapy, a type of regenerative medicine with the patient’s own blood, uses components called platelets in the blood to rejuvenate the skin. Based on an innate wound-healing ability, the therapy is performed by injecting components collected from the blood and is associated with no risk of allergy or infections. The safe therapy has been studied and applied in a variety of fields. It is indicated for a wide variety of conditions; it is used for the treatment of trauma and burn in the department of plastic surgery and also used as an adjunct to implant therapy in the department of dentistry.

Our clinics have introduced a new technology for extraction of platelet-rich plasma containing autologous white blood cells that has a PRP enrichment rate of about 6- to 10-fold (about three to five times higher than that for conventional one) and contains white blood cells, which are not contained in conventional PRP. The therapy is found to have much greater efficacy in rejuvenating the skin, eliminating wrinkles, and reducing irregularities from acne marks compared with conventional therapy.

Interaction between PRP and white blood cells results in the release of growth factors that potentiate the natural healing power and tissue reorganization potential at injection sites and subsequent regeneration of the skin.

In conventional therapy, it takes about two months for any benefit to be seen, although the time varies among individuals. New-PRP Skin Regeneration Therapy produces noticeable symptomatic improvement in a short period of about two weeks.

The PRP enrichment rate is three to five times higher than that for conventional procedures, and the time to benefit is reduced to one-fourth.

※Means calculated from our clinical data

PRP Skin Regeneration Therapy uses components called platelets contained in the blood. Platelets play a role in stopping bleeding and repairing damaged blood vessels and cells in the body. Platelets contain substances called growth factors that activate and rejuvenate cells in the body. The growth factors, when released, induce the production of collagen and generation of new capillaries to rejuvenate the skin.

Many clinics now use what they call “autologous platelets” to eliminate wrinkles and treat acne marks. All those clinics claim “skin regeneration therapy with autologous platelets.” However, the efficacy of therapy differs substantially.

Important factors for greater efficacy include the concentration and component of platelets for injection. As described previously, skin regeneration with PRP is based on the mechanism that platelets release a variety of growth factors to promote tissue repair, angiogenesis, and collagen production for skin rejuvenation.

The efficacy is enhanced by improving the quality of platelets. Our clinics use a method of injecting platelet-rich plasma containing autologous white blood cells that is prepared by mixing enriched platelets (6 to 10 fold) collected from blood and an appropriate amount of white blood cells, which are rarely contained in common PRP. Our method is found to be highly effective in a range of symptoms.

PRP Skin Regeneration Therapy uses components called platelets contained in the blood. Platelets play a role in stopping bleeding and repairing damaged blood vessels and cells in the body. Platelets contain substances called growth factors that activate and rejuvenate cells in the body. The growth factors, when released, induce the production of collagen and generation of new capillaries to rejuvenate the skin.

For separation of platelet-rich plasma (PRP), a dedicated kit called Fibrinet AGF is used. The use of a specific filter and a centrifuge achieves a high platelet recovery rate of 97% or more and allows preparation of plasma containing six to ten times as many platelets as the common one.

The blood is collected.

A specific filter and a centrifuge are used to prepare platelet-rich plasma (PRP) containing autologous white blood cells.

The platelet-rich plasma (PRP) with autologous white blood cells is injected into the area of concern. It takes about 30 to 40 minutes from blood collection to injection.

Platelets and white blood cells exert a synergistic effect, resulting in the release of a variety of growth factors at the injection sites. This promotes the production of collagen and hyaluronic acid and wound healing, leading to improvement of symptoms such as wrinkles and irregularities from acne marks.

PRP Skin Regeneration Therapy is expected to provide great benefit for crepy skin under the eyes, which are difficult to treat with conventional rejuvenating injections and laser therapy. The therapy uses the patient’s own blood for rejuvenation and thus poses no risk of infection or allergy. It has the advantage of a longer duration of efficacy compared with injection of hyaluronic acid and collagen that are absorbed into the body. Other features such as no need for skin incision and short downtime (swelling usually resolves in two to three hours) make this therapy a safe treatment.
* When injection is performed under the eyes, redness may persist for two to three days but resolve over time.

Specific treatment	Injection of platelet-rich plasma containing autologous white blood cells collected from the blood. Use of regenerative power of the skin.	Injection of medical-grade hyaluronic acid or collagen for maintenance of firm skin, or injection of Botox to reduce the movement of muscles.
Benefit	Crepy skin under the eyes, fine wrinkles in the face, nasolabial grooves, acne marks, sagged skin, etc	Nip and tuck for fine wrinkles in the whole face, wrinkles on the neck and hands, nasolabial grooves, wrinkles between the eyebrows and forehead, expression wrinkles at the corner of the eyes, chin, nose, etc.
Adverse reaction	Infections and allergy do not occur because the patient’s own blood components are used.	Unlikely to occur.
Effectine period	About 1 year	Absorbed in about 0.5 to 1year
Re-injection	The blood is not absorbed, and thus repeated injections are not necessary (additional injection is allowed).	Repeated injections are necessary because those agents are absorbed into the body.
Costs for 1 session	1 site(2cc): 200,000 yen	Hyaluronic acid, 1 site: 98,000 yen Collagen (Evolence), 1 site: 150,000 yen Botox, 1 site: 50,000 yen or more

*Before treatment, consult a physician about the best procedure, which depends on the sites and conditions of the wrinkles and others symptoms.

Another feature of the therapy is that the patient will experience a natural change in the operative site and minimal discomfort because beneficial effects gradually occur after about two weeks of therapy.